Negative pressure wound therapy (NPWT) benefits patients with difficult surgical wounds by reducing the risk of surgical site infections (SSIs)Īnd surgical complications, including dehiscence, seroma/hematoma, skin necrosis/blistering,Īnd postoperative mortality rate as shown in previous meta‐analyses. NPWT can be considered an alternative method for reconstruction in challenging cases. Application of NPWT in oncologic resection wounds without residual malignancy revealed no difference in local recurrence and may reduce the risk of postoperative complications compared with conventional non‐negative pressure dressings. Although NTWT was associated with a lower complication rate compared with the control group, the result was non‐significant ( P = 0.15). There was no significant heterogeneity between the studies (I 2 = 3%). Tumour recurrence after NPWT was not significantly different compared with conventional non‐negative pressure wound care (9.3% versus 11.4%, P = 0.40). The overall quality of the included studies was high based on the Newcastle–Ottawa scale score of 7.5. The six studies included 118 patients who received NPWT, and 149 patients who received conventional non‐pressure wound care. We compared tumour recurrence rates and postoperative complications between the two procedures. To evaluate the association of NPWT with oncologic recurrence in surgical wounds without residual malignancy, we analysed studies that compared NPWT with conventional non‐pressure dressings for cancer surgical wounds without residual tumour by August 12, 2020. However, the use of NPWT for oncological surgical wounds remains controversial. © 2017 Inc and John Wiley & Sons Ltd.Negative pressure wound therapy (NPWT) decreases postoperative complications of various surgeries. Despite the encouraging data, it is necessary to broaden the sample of patients and perform the same study with other antibiotics.Ĭhronic wound Daptomicin Negative pressure wound therapy Vacuum Assisted Closure therapy. The preliminary analysis of the data showed an important increase of antibiotic concentration in the tissue after VAC therapy. Statistical differences were not found between the two groups. The results highlighted a significant increase in the concentration of antibiotics in the study group tissue the improvement was sensibly lower in the control group. Fisher's exact test was used to compare the two groups. A control group was enrolled in which patients followed the same protocol, but they were treated with traditional dressings. At the end of VAC therapy, a second lesion biopsy was performed and analysed to detect tissue concentration of the drug at time 1. Afterwards, the patients were subjected to VAC therapy. A biopsy of the lesion was carried out to detect tissue concentration of the drug at time 0. They were given antibiotic therapy with daptomycin with a specific protocol. Patients who presented with ulcers infected with daptomycin-sensitive bacteria were eligible to be enrolled in this prospective study. The objective of this study is to extend the indications for VAC therapy to include infected wounds by demonstrating its ability to increase the antibiotic concentration in the damaged and infected tissues. Wound infection is considered a relative contraindication. Vacuum-assisted closure (VAC) therapy is a sophisticated system that maintains a closed, humid, sterile and isolated environment.
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